Pimozide and Imipramine Blue Exploit Mitochondrial Vulnerabilities and Reactive Oxygen Species to Cooperatively Target High Risk Acute Myeloid Leukemia

• Asıl Yazarlar: Zhengqi Wang (Yazar), Tian Mi (Yazar), Heath L. Bradley (Yazar), Jonathan Metts (Yazar), Himalee Sabnis (Yazar), Wandi Zhu (Yazar), Jack Arbiser (Yazar), Kevin D. Bunting (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2021-06-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Acute myeloid leukemia (AML) is a heterogeneous disease with a high relapse rate. Cytokine receptor targeted therapies are therapeutically attractive but are subject to resistance-conferring mutations. Likewise, targeting downstream signaling pathways has been difficult. Recent success in the develo...