Synthesis, Characterization, and In Vitro Studies of an Reactive Oxygen Species (ROS)-Responsive Methoxy Polyethylene Glycol-Thioketal-Melphalan Prodrug for Glioblastoma Treatment

• Main Authors: Natalia Oddone (Author), Frank Boury (Author), Emmanuel Garcion (Author), Andreas M. Grabrucker (Author), M. Carmen Martinez (Author), Federica Da Ros (Author), Anna Janaszewska (Author), Flavio Forni (Author), Maria Angela Vandelli (Author), Giovanni Tosi (Author), Barbara Ruozi (Author), Jason T. Duskey (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glioblastoma (GBM) is the most frequent and aggressive primary tumor of the brain and averages a life expectancy in diagnosed patients of only 15 months. Hence, more effective therapies against this malignancy are urgently needed. Several diseases, including cancer, are featured by high levels of re...