The Aggravation of Clozapine-Induced Hepatotoxicity by Glycyrrhetinic Acid in Rats

• Main Authors: Ling-ling Jia (Author), Ze-yu Zhong (Author), Feng Li (Author), Zhao-li Ling (Author), Yang Chen (Author), Wei-man Zhao (Author), Ying Li (Author), Shu-wen Jiang (Author), Ping Xu (Author), Yang Yang (Author), Meng-yue Hu (Author), Li Liu (Author), Xiao-dong Liu (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Clozapine (CLZ) was reported to be associated with hepatotoxicity. Glycyrrhetinic acid (GA) has a liver protective effect. Our preliminary experiments showed that GA aggravated rather than attenuated CLZ-induced hepatotoxicity in primary cultured rat hepatocytes. The study aimed to describe the enha...