The human antibody sequence space and structural design of the V, J regions, and CDRH3 with Rosetta

The human adaptive immune response enables the targeting of epitopes on pathogens with high specificity. Infection with a pathogen induces somatic hyper-mutation and B-cell selection processes that govern the shape and diversity of the antibody sequence landscape. To date, even the largest immunome...

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Autores principales: Samuel Schmitz (Autor), Emily A. Schmitz (Autor), James E. Crowe (Autor), Jens Meiler (Autor)
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Publicado: Taylor & Francis Group, 2022-12-01T00:00:00Z.
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