Development of Bisphosphonate-Conjugated Antibiotics to Overcome Pharmacodynamic Limitations of Local Therapy: Initial Results with Carbamate Linked Sitafloxacin and Tedizolid

• Main Authors: Emmanuela Adjei-Sowah (Author), Yue Peng (Author), Jason Weeks (Author), Jennifer H. Jonason (Author), Karen L. de Mesy Bentley (Author), Elysia Masters (Author), Yugo Morita (Author), Gowrishankar Muthukrishnan (Author), Philip Cherian (Author), X. Eric Hu (Author), Charles E. McKenna (Author), Frank H. Ebetino (Author), Shuting Sun (Author), Edward M. Schwarz (Author), Chao Xie (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The use of local antibiotics to treat bone infections has been questioned due to a lack of clinical efficacy and emerging information about <i>Staphylococcus aureus</i> colonization of the osteocyte-lacuno canalicular network (OLCN). Here we propose bisphosphonate-conjugated antibiotics...