Development of Bisphosphonate-Conjugated Antibiotics to Overcome Pharmacodynamic Limitations of Local Therapy: Initial Results with Carbamate Linked Sitafloxacin and Tedizolid

• मुख्य लेखकों: Emmanuela Adjei-Sowah (लेखक), Yue Peng (लेखक), Jason Weeks (लेखक), Jennifer H. Jonason (लेखक), Karen L. de Mesy Bentley (लेखक), Elysia Masters (लेखक), Yugo Morita (लेखक), Gowrishankar Muthukrishnan (लेखक), Philip Cherian (लेखक), X. Eric Hu (लेखक), Charles E. McKenna (लेखक), Frank H. Ebetino (लेखक), Shuting Sun (लेखक), Edward M. Schwarz (लेखक), Chao Xie (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2021-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The use of local antibiotics to treat bone infections has been questioned due to a lack of clinical efficacy and emerging information about <i>Staphylococcus aureus</i> colonization of the osteocyte-lacuno canalicular network (OLCN). Here we propose bisphosphonate-conjugated antibiotics...