Development of Bisphosphonate-Conjugated Antibiotics to Overcome Pharmacodynamic Limitations of Local Therapy: Initial Results with Carbamate Linked Sitafloxacin and Tedizolid
The use of local antibiotics to treat bone infections has been questioned due to a lack of clinical efficacy and emerging information about <i>Staphylococcus aureus</i> colonization of the osteocyte-lacuno canalicular network (OLCN). Here we propose bisphosphonate-conjugated antibiotics...
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| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Book |
| Published: |
MDPI AG,
2021-06-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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