Altered cytoplasmic and nuclear ADP‐ribosylation levels analyzed with an improved ADP‐ribose binder are a prognostic factor in renal cell carcinoma

• Hoofdauteurs: Peter Schraml (Auteur), Fabio Aimi (Auteur), Martin Zoche (Auteur), Domingo Aguilera‐Garcia (Auteur), Fabian Arnold (Auteur), Holger Moch (Auteur), Michael O Hottiger (Auteur)
• Formaat: Boek
• Gepubliceerd in: Wiley, 2023-07-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Abstract ADP‐ribosylation (ADPR) of proteins is catalyzed by ADP‐ribosyltransferases, which are targeted by inhibitors (i.e. poly(ADP‐ribose) polymerase inhibitors [PARPi]). Although renal cell carcinoma (RCC) cells are sensitive in vitro to PARPi, studies on the association between ADPR levels and...