Altered cytoplasmic and nuclear ADP‐ribosylation levels analyzed with an improved ADP‐ribose binder are a prognostic factor in renal cell carcinoma

• Egile Nagusiak: Peter Schraml (Egilea), Fabio Aimi (Egilea), Martin Zoche (Egilea), Domingo Aguilera‐Garcia (Egilea), Fabian Arnold (Egilea), Holger Moch (Egilea), Michael O Hottiger (Egilea)
• Formatua: Liburua
• Argitaratua: Wiley, 2023-07-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Abstract ADP‐ribosylation (ADPR) of proteins is catalyzed by ADP‐ribosyltransferases, which are targeted by inhibitors (i.e. poly(ADP‐ribose) polymerase inhibitors [PARPi]). Although renal cell carcinoma (RCC) cells are sensitive in vitro to PARPi, studies on the association between ADPR levels and...