Thromboxane Modulates Endothelial Permeability

• Main Authors: J. M. Klausner (Author), S. Abu-Abid (Author), J. S. Alexander (Author), R. Hanshke-Mineau (Author), G. Goldman (Author), N. Morel (Author), C. R. Valeri (Author), D. Shepro (Author), H. B. Hechtman (Author)
• Format: Book
• Published: Hindawi Limited, 1994-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The study tests the role of thromboxane in modulating microvascular permeability in vitro. Cultured monolayers of bovine aortic endothelial cells were challenged with the thromboxane (Tx) mimic U46619. This led to disassembly of actin microfilaments, cell rounding, border retraction and interendothe...