Self-assembled angiopep-2 modified lipid-poly (hypoxic radiosensitized polyprodrug) nanoparticles delivery TMZ for glioma synergistic TMZ and RT therapy

• Main Authors: Zhenkun Zong (Author), Lei Hua (Author), Zhen Wang (Author), Haoyue Xu (Author), Chengkun Ye (Author), Bomin Pan (Author), Zongren Zhao (Author), Longzhen Zhang (Author), Jun Lu (Author), Hongmei Liu (Author), Rutong Yu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The addition of temozolomide (TMZ) to radiotherapy (RT) improves survival of patients with glioblastoma (GBM). However, TMZ + RT causes excess toxicity in patients. In this study, we prepared angiopep-2 (A2) modified lipid-poly (hypoxic radiosensitized polyprodrug) nanoparticles for TMZ delivery (A2...