Development of a Zebrafish Sepsis Model for High-Throughput Drug Discovery

• Main Authors: Anju M. Philip (Author), Youdong Wang (Author), Antonio Mauro (Author), Suzan El-Rass (Author), John C. Marshall (Author), Warren L. Lee (Author), Arthur S. Slutsky (Author), Claudia C. dos Santos (Author), Xiao-Yan Wen (Author)
• Format: Book
• Published: BMC, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Sepsis is a leading cause of death worldwide. Current treatment modalities remain largely supportive. Intervention strategies focused on inhibiting specific mediators of the inflammatory host response have been largely unsuccessful, a consequence of an inadequate understanding of the comple...