Adeno-Associated Virus-Mediated RNAi against Mutant Alleles Attenuates Abnormal Calvarial Phenotypes in an Apert Syndrome Mouse Model

Apert syndrome (AS), the most severe form of craniosynostosis, is caused by missense mutations including Pro253Arg(P253R) of fibroblast growth factor receptor 2 (FGFR2), which leads to enhanced FGF/FGFR2-signaling activity. Surgical correction of the deformed skull is the typical treatment for AS. B...

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Main Authors: Fengtao Luo (Author), Yangli Xie (Author), Zuqiang Wang (Author), Junlan Huang (Author), Qiaoyan Tan (Author), Xianding Sun (Author), Fangfang Li (Author), Can Li (Author), Mi Liu (Author), Dali Zhang (Author), Meng Xu (Author), Nan Su (Author), Zhenhong Ni (Author), Wanling Jiang (Author), Jinhong Chang (Author), Hangang Chen (Author), Shuai Chen (Author), Xiaoling Xu (Author), Chuxia Deng (Author), Zhugang Wang (Author), Xiaolan Du (Author), Lin Chen (Author)
Format: Book
Published: Elsevier, 2018-12-01T00:00:00Z.
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