Design and Comprehensive Characterization of Tetramethylpyrazine (TMP) for Targeted Lung Delivery as Inhalation Aerosols in Pulmonary Hypertension (PH): In Vitro Human Lung Cell Culture and In Vivo Efficacy

• Autori principali: Priya Muralidharan (Autore), Maria F. Acosta (Autore), Alexan I. Gomez (Autore), Carissa Grijalva (Autore), Haiyang Tang (Autore), Jason X.-J. Yuan (Autore), Heidi M. Mansour (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2021-03-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

This is the first study reporting on the design and development innovative inhaled formulations of the novel natural product antioxidant therapeutic, tetramethylpyrazine (TMP), also known as ligustrazine. TMP is obtained from Chinese herbs belonging to the class of <i>Ligusticum</i>. It...