Latent TGFβ-binding proteins 1 and 3 protect the larval zebrafish outflow tract from aneurysmal dilatation

• Main Authors: Maryline Abrial (Author), Sandeep Basu (Author), Mengmeng Huang (Author), Vincent Butty (Author), Asya Schwertner (Author), Spencer Jeffrey (Author), Daniel Jordan (Author), Caroline E. Burns (Author), C. Geoffrey Burns (Author)
• Format: Book
• Published: The Company of Biologists, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aortic root aneurysm is a common cause of morbidity and mortality in Loeys-Dietz and Marfan syndromes, where perturbations in transforming growth factor beta (TGFβ) signaling play a causal or contributory role, respectively. Despite the advantages of cross-species disease modeling, animal models of...