The effects of glutamine supplementation on markers of apoptosis and autophagy in sickle cell disease peripheral blood mononuclear cells

• Main Authors: Patrick B. Walter (Author), Leah S. Hohman (Author), Andrew Rokeby (Author), Julian J. Lum (Author), Robert Hagar (Author), Lisa Lavrisha (Author), Augusta Saulys (Author), Frans A. Kuypers (Author), Elliott Vichinsky (Author), Claudia R. Morris (Author)
• Format: Book
• Published: Elsevier, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: L-Glutamine was FDA-approved for sickle cell disease (SCD) in 2017, yet the mechanism(s)-of-action are poorly understood. This study investigates the potential activation of autophagy as a previously unexplored mechanism-of-benefit. Design: Prospective, open-label, 8-week, phase-2 trial...