Design and synthesis of cabotegravir derivatives bearing 1,2,3-triazole and evaluation of anti-liver cancer activity

• Main Authors: Huaxia Xie (Author), Longfei Mao (Author), Gaolu Fan (Author), Ziyuan Wu (Author), Yimian Wang (Author), Xixi Hou (Author), Jiangang Wang (Author), Huili Wang (Author), Ling Liu (Author), Sanqiang Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Based on the structure of the anti-HIV drug cabotegravir, we introduced 1,2,3-triazole groups with different substituents to obtain 19 cabotegravir derivatives and tested their activity against HepG2 cells. The proliferation of HepG2 cells was examined following treatment with derivatives. Most of t...