Gentiopicroside Ameliorates Diabetic Renal Tubulointerstitial Fibrosis via Inhibiting the AT1R/CK2/NF-κB Pathway

• Main Authors: Zhanchi Xu (Author), Meng Zhang (Author), Yu Wang (Author), Rui Chen (Author), Shiyue Xu (Author), Xiaohong Sun (Author), Yan Yang (Author), Zeyuan Lin (Author), Shaogui Wang (Author), Heqing Huang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Renal tubulointerstitial fibrosis (TIF), characterized by epithelial-to-mesenchymal transition (EMT) of renal tubular epithelial cells, is the typical pathological alteration in diabetic nephropathy. Gentiopicroside (GPS), a natural compound with anti-inflammatory activity, has been demonstrated to...