Successful pregnancy after prenatal diagnosis by NGS for a carrier of complex chromosome rearrangements

• Main Authors: Jian Ou (Author), Chuanchun Yang (Author), Xiaoli Cui (Author), Chuan Chen (Author), Suyan Ye (Author), Cai Zhang (Author), Kai Wang (Author), Jianguo Chen (Author), Qin Zhang (Author), Chunfeng Qian (Author), Guangguang Fang (Author), Wenyong Zhang (Author)
• Format: Book
• Published: BMC, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The study is aimed to provide prediction for fertility risk in the setting of assisted reproduction for a woman with complex chromosomal rearrangements (CCRs). Methods We implemented a robust approach, which combined whole-genome low-coverage mate-pair sequencing (WGL-MPS), junct...