Population pharmacokinetics of everolimus in patients with seizures associated with focal cortical dysplasia

• Main Authors: Jinha Park (Author), Se Hee Kim (Author), Jongsung Hahn (Author), Hoon-Chul Kang (Author), Sang-Guk Lee (Author), Heung Dong Kim (Author), Min Jung Chang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Everolimus is an inhibitor of mammalian target of rapamycin complex 1. As mutations in TSC1 and TSC2, which cause partial-onset seizures associated with TSC, were found in focal cortical dysplasia type Ⅱ (FCD Ⅱ) patients, a clinical trial has been performed to explore the efficacy and sa...