Implementing a pragmatic clinical trial to tailor opioids for chronic pain on behalf of the IGNITE ADOPT PGx investigators

• Main Authors: Todd C. Skaar (Author), Rachel A. Myers (Author), Roger B. Fillingim (Author), John T. Callaghan (Author), Emily Cicali (Author), Michael T. Eadon (Author), Erica N. Elwood (Author), Geoffrey S. Ginsburg (Author), Sheryl Lynch (Author), Khoa A. Nguyen (Author), Aniwaa Owusu Obeng (Author), Haesuk Park (Author), Victoria M. Pratt (Author), Marc Rosenman (Author), Azita Sadeghpour (Author), Saskia Shuman (Author), Rajbir Singh (Author), Emma M. Tillman (Author), Simona Volpi (Author), Kristin Wiisanen (Author), Almut G. Winterstein (Author), Carol R. Horowitz (Author), Deepak Voora (Author), Lori Orlando (Author), Hrishikesh Chakraborty (Author), Sara Van Driest (Author), Josh F. Peterson (Author), Larisa A. Cavallari (Author), Julie A. Johnson (Author), Paul R. Dexter (Author), the IGNITE Pragmatic Trials Network (Author)
• Format: Book
• Published: Wiley, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Chronic pain is a prevalent condition with enormous economic burden. Opioids such as tramadol, codeine, and hydrocodone are commonly used to treat chronic pain; these drugs are activated to more potent opioid receptor agonists by the hepatic CYP2D6 enzyme. Results from clinical studies and...