Uric Acid-Induced Adipocyte Dysfunction Is Attenuated by HO-1 Upregulation: Potential Role of Antioxidant Therapy to Target Obesity

• Egile Nagusiak: Komal Sodhi (Egilea), Jordan Hilgefort (Egilea), George Banks (Egilea), Chelsea Gilliam (Egilea), Sarah Stevens (Egilea), Hayden A. Ansinelli (Egilea), Morghan Getty (Egilea), Nader G. Abraham (Egilea), Joseph I. Shapiro (Egilea), Zeid Khitan (Egilea)
• Formatua: Liburua
• Argitaratua: Hindawi Limited, 2016-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Increased uric acid levels have been implicated in the pathogenesis of metabolic syndrome. To examine the mechanisms by which this occurs, we hypothesized that an increase in heme oxygenase 1, a potent antioxidant gene, will decrease uric acid levels and adipocyte dysfunction via suppression of ROS...