A spontaneous leptin receptor point mutation causes obesity and differentially affects leptin signaling in hypothalamic nuclei resulting in metabolic dysfunctions distinct from db/db mice

• Main Authors: Federica Piattini (Author), Christelle Le Foll (Author), Jan Kisielow (Author), Esther Rosenwald (Author), Peter Nielsen (Author), Thomas Lutz (Author), Christoph Schneider (Author), Manfred Kopf (Author)
• Format: Book
• Published: Elsevier, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Leptin (Lep) plays a crucial role in controlling food intake and energy expenditure. Defective Lep/LepRb-signaling leads to fat accumulation, massive obesity, and the development of diabetes. We serendipitously noticed spontaneous development of obesity similar to LepR-deficient (db/db) m...