Isolation of monoclonal antibodies from anti-synthetase syndrome patients and affinity maturation by recombination of independent somatic variants

• Main Authors: Luke Burman (Author), Yeeting E. Chong (Author), Sherie Duncan (Author), Anders Klaus (Author), Kaitlyn Rauch (Author), Kristina Hamel (Author), Karine Hervé (Author), Stephanie Pfaffen (Author), David W. Collins (Author), Kevin Heyries (Author), Leslie Nangle (Author), Carl Hansen (Author), David J. King (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The autoimmune disease known as Jo-1 positive anti-synthetase syndrome (ASS) is characterized by circulating antibody titers to histidyl-tRNA synthetase (HARS), which may play a role in modulating the non-canonical functions of HARS. Monoclonal antibodies to HARS were isolated by single-cell screeni...