Isolation of monoclonal antibodies from anti-synthetase syndrome patients and affinity maturation by recombination of independent somatic variants

• Үндсэн зохиолчид: Luke Burman (Зохиогч), Yeeting E. Chong (Зохиогч), Sherie Duncan (Зохиогч), Anders Klaus (Зохиогч), Kaitlyn Rauch (Зохиогч), Kristina Hamel (Зохиогч), Karine Hervé (Зохиогч), Stephanie Pfaffen (Зохиогч), David W. Collins (Зохиогч), Kevin Heyries (Зохиогч), Leslie Nangle (Зохиогч), Carl Hansen (Зохиогч), David J. King (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

The autoimmune disease known as Jo-1 positive anti-synthetase syndrome (ASS) is characterized by circulating antibody titers to histidyl-tRNA synthetase (HARS), which may play a role in modulating the non-canonical functions of HARS. Monoclonal antibodies to HARS were isolated by single-cell screeni...