Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion

• Main Authors: Susanne Keipert (Author), Maria Kutschke (Author), Daniel Lamp (Author), Laura Brachthäuser (Author), Frauke Neff (Author), Carola W. Meyer (Author), Rebecca Oelkrug (Author), Alexei Kharitonenkov (Author), Martin Jastroch (Author)
• Format: Book
• Published: Elsevier, 2015-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Circulating fibroblast growth factor 21 (FGF21) is an important auto- and endocrine player with beneficial metabolic effects on obesity and diabetes. In humans, thermogenic brown adipose tissue (BAT) was recently suggested as a source of FGF21 secretion during cold exposure. Here, we aim...