Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion

• Principais autores: Susanne Keipert (Autor), Maria Kutschke (Autor), Daniel Lamp (Autor), Laura Brachthäuser (Autor), Frauke Neff (Autor), Carola W. Meyer (Autor), Rebecca Oelkrug (Autor), Alexei Kharitonenkov (Autor), Martin Jastroch (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2015-07-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Objective: Circulating fibroblast growth factor 21 (FGF21) is an important auto- and endocrine player with beneficial metabolic effects on obesity and diabetes. In humans, thermogenic brown adipose tissue (BAT) was recently suggested as a source of FGF21 secretion during cold exposure. Here, we aim...