Paeonol Protects against Methotrexate Hepatotoxicity by Repressing Oxidative Stress, Inflammation, and Apoptosis-The Role of Drug Efflux Transporters

• Asıl Yazarlar: Mohamed A. Morsy (Yazar), Rania Abdel-Latif (Yazar), Sara Mohamed Naguib Abdel Hafez (Yazar), Mahmoud Kandeel (Yazar), Seham A. Abdel-Gaber (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2022-10-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Methotrexate (MTX) is an effective chemotherapeutic agent against a wide range of tumors and autoimmune diseases; however, hepatotoxicity limits its clinical use. Oxidative stress and inflammation have been implicated in the pathogenesis of MTX-induced hepatotoxicity. Paeonol is a natural phenolic c...