Orthogonal assays for the identification of inhibitors of the single-stranded nucleic acid binding protein YB-1

• Main Authors: AlexanderJ. Trevarton (Author), Yan Zhou (Author), Dehua Yang (Author), Gordon W. Rewcastle (Author), Jack U. Flanagan (Author), Antony Braithwaite (Author), Peter R. Shepherd (Author), Cristin G. Print (Author), Ming-Wei Wang (Author), Annette Lasham (Author)
• Format: Book
• Published: Elsevier, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have previously shown that high expression of the nucleic acid binding factor YB-1 is strongly associated with poor prognosis in a variety of cancer types. The 3-dimensional protein structure of YB-1 has yet to be determined and its role in transcriptional regulation remains elusive. Drug targeti...