Orthogonal assays for the identification of inhibitors of the single-stranded nucleic acid binding protein YB-1

• 主要な著者: AlexanderJ. Trevarton (著者), Yan Zhou (著者), Dehua Yang (著者), Gordon W. Rewcastle (著者), Jack U. Flanagan (著者), Antony Braithwaite (著者), Peter R. Shepherd (著者), Cristin G. Print (著者), Ming-Wei Wang (著者), Annette Lasham (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2019-09-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

We have previously shown that high expression of the nucleic acid binding factor YB-1 is strongly associated with poor prognosis in a variety of cancer types. The 3-dimensional protein structure of YB-1 has yet to be determined and its role in transcriptional regulation remains elusive. Drug targeti...