Effect of aging on the formation and growth of colonic epithelial organoids by changes in cell cycle arrest through TGF-β-Smad3 signaling

• Main Authors: Min Kyoung Jo (Author), Chang Mo Moon (Author), Hyeon-Jeong Jeon (Author), Yerim Han (Author), Eun Sook Lee (Author), Ji-Hee Kwon (Author), Kyung-Min Yang (Author), Young-Ho Ahn (Author), Seong-Eun Kim (Author), Sung-Ae Jung (Author), Tae Il Kim (Author)
• Format: Book
• Published: BMC, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background This study aimed to investigate how aging alters the homeostasis of the colonic intestinal epithelium and regeneration after tissue injury using organoid models and to identify its underlying molecular mechanism. Methods To investigate aging-related changes in the colonic intesti...