Green Tea Catechins Induce Inhibition of PTP1B Phosphatase in Breast Cancer Cells with Potent Anti-Cancer Properties: In Vitro Assay, Molecular Docking, and Dynamics Studies

• Main Authors: Alicja Kuban-Jankowska (Author), Tomasz Kostrzewa (Author), Claudia Musial (Author), Giampaolo Barone (Author), Giosuè Lo-Bosco (Author), Fabrizio Lo-Celso (Author), Magdalena Gorska-Ponikowska (Author)
• Format: Book
• Published: MDPI AG, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The catechins derived from green tea possess antioxidant activity and may have a potentially anticancer effect. PTP1B is tyrosine phosphatase that is oxidative stress regulated and is involved with prooncogenic pathways leading to the formation of a.o. breast cancer. Here, we present the effect of s...