Development of a LC-ESI-MRM method for the absolute quantification of orexin A in the CSF of individual mice

• Váldodahkkit: Katherine Hopkins (Dahkki), Soumya Mukherjee (Dahkki), Dalia Ponce (Dahkki), Jonathan Mangum (Dahkki), Laura H. Jacobson (Dahkki), Daniel Hoyer (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2021-09-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Sleep-wakefulness is disrupted in most neurological and psychiatric disorders. Although clinical data implicate orexin (hypocretin), a crucial sleep/wake regulatory neuropeptide, in such disorders, limited sample volumes effectively prevent quantification of cerebrospinal fluid (CSF) levels of orexi...