Development of a LC-ESI-MRM method for the absolute quantification of orexin A in the CSF of individual mice

• 主要な著者: Katherine Hopkins (著者), Soumya Mukherjee (著者), Dalia Ponce (著者), Jonathan Mangum (著者), Laura H. Jacobson (著者), Daniel Hoyer (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2021-09-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Sleep-wakefulness is disrupted in most neurological and psychiatric disorders. Although clinical data implicate orexin (hypocretin), a crucial sleep/wake regulatory neuropeptide, in such disorders, limited sample volumes effectively prevent quantification of cerebrospinal fluid (CSF) levels of orexi...