Peripheral cannabinoid-1 receptor blockade restores hypothalamic leptin signaling

• Asıl Yazarlar: Joseph Tam (Yazar), Gergő Szanda (Yazar), Adi Drori (Yazar), Ziyi Liu (Yazar), Resat Cinar (Yazar), Yoshihiro Kashiwaya (Yazar), Marc L. Reitman (Yazar), George Kunos (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2017-10-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Objective: In visceral obesity, an overactive endocannabinoid/CB1 receptor (CB1R) system promotes increased caloric intake and decreases energy expenditure, which are mitigated by global or peripheral CB1R blockade. In mice with diet-induced obesity (DIO), inhibition of food intake by the peripheral...