Peripheral cannabinoid-1 receptor blockade restores hypothalamic leptin signaling

• Main Authors: Joseph Tam (Author), Gergő Szanda (Author), Adi Drori (Author), Ziyi Liu (Author), Resat Cinar (Author), Yoshihiro Kashiwaya (Author), Marc L. Reitman (Author), George Kunos (Author)
• Format: Book
• Published: Elsevier, 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: In visceral obesity, an overactive endocannabinoid/CB1 receptor (CB1R) system promotes increased caloric intake and decreases energy expenditure, which are mitigated by global or peripheral CB1R blockade. In mice with diet-induced obesity (DIO), inhibition of food intake by the peripheral...