Peripheral cannabinoid-1 receptor blockade restores hypothalamic leptin signaling

• Hoofdauteurs: Joseph Tam (Auteur), Gergő Szanda (Auteur), Adi Drori (Auteur), Ziyi Liu (Auteur), Resat Cinar (Auteur), Yoshihiro Kashiwaya (Auteur), Marc L. Reitman (Auteur), George Kunos (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2017-10-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Objective: In visceral obesity, an overactive endocannabinoid/CB1 receptor (CB1R) system promotes increased caloric intake and decreases energy expenditure, which are mitigated by global or peripheral CB1R blockade. In mice with diet-induced obesity (DIO), inhibition of food intake by the peripheral...