Neuroprotective effect of S-allyl-l-cysteine derivatives against endoplasmic reticulum stress-induced cytotoxicity is independent of calpain inhibition

• Main Authors: Toru Imai (Author), Yasuhiro Kosuge (Author), Hiroaki Saito (Author), Taketo Uchiyama (Author), Taira Wada (Author), Shigeki Shimba (Author), Kumiko Ishige (Author), Shinichi Miyairi (Author), Makoto Makishima (Author), Yoshihisa Ito (Author)
• Format: Book
• Published: Elsevier, 2016-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

S-allyl-l-cysteine (SAC) is known to have neuroprotective properties. We synthesized various SAC derivatives and tested their effects on endoplasmic reticulum stress-induced neurotoxicity in cultured hippocampal neurons (HPNs). Among the compounds tested, S-propyl-l-cysteine (SPC) exhibited the stro...