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Neuroprotective effect of S-allyl-l-cysteine derivatives against endoplasmic reticulum stress-induced cytotoxicity is independent of calpain inhibition

S-allyl-l-cysteine (SAC) is known to have neuroprotective properties. We synthesized various SAC derivatives and tested their effects on endoplasmic reticulum stress-induced neurotoxicity in cultured hippocampal neurons (HPNs). Among the compounds tested, S-propyl-l-cysteine (SPC) exhibited the stro...

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Main Authors: Toru Imai (Author), Yasuhiro Kosuge (Author), Hiroaki Saito (Author), Taketo Uchiyama (Author), Taira Wada (Author), Shigeki Shimba (Author), Kumiko Ishige (Author), Shinichi Miyairi (Author), Makoto Makishima (Author), Yoshihisa Ito (Author)
Format: Book
Published: Elsevier, 2016-03-01T00:00:00Z.
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Summary:S-allyl-l-cysteine (SAC) is known to have neuroprotective properties. We synthesized various SAC derivatives and tested their effects on endoplasmic reticulum stress-induced neurotoxicity in cultured hippocampal neurons (HPNs). Among the compounds tested, S-propyl-l-cysteine (SPC) exhibited the strongest neuroprotective activity in HPNs, followed by S-ethyl-l-cysteine (SEC) and S-methyl-l-cysteine (SMC). Unlike SAC and SMC, SPC and SEC did not have inhibitory activity on μ-calpain, suggesting that the mechanism underlying the protective activity of SPC and SEC differs from that of SAC.
Item Description:1347-8613
10.1016/j.jphs.2016.03.004

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