A case of Turcot's syndrome type 1 with loss of immunoexpression of MSH6 in colon cancer and liver metastasis due to secondary somatic mutation in coding mononucleotide (C)8 tract: a case report

• Main Authors: Shintaro Akabane (Author), Takao Hinoi (Author), Kiwamu Akagi (Author), Hideki Yamamoto (Author), Haruki Sada (Author), Yosuke Shimizu (Author), Wataru Shimizu (Author), Takeshi Sudo (Author), Takashi Onoe (Author), Kohei Ishiyama (Author), Takahisa Suzuki (Author), Hirofumi Tazawa (Author), Naoto Hadano (Author), Toshihiro Misumi (Author), Masato Kojima (Author), Haruna Kubota (Author), Daiki Taniyama (Author), Kazuya Kuraoka (Author), Hirotaka Tashiro (Author)
• Format: Book
• Published: BMC, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Lynch syndrome (LS), which is known as a hereditary cancer syndrome, is distinguished by microsatellite instability, represented by the altered number of repetitive sequences in the coding and/or non-coding region. Immunohistochemical staining (IHC) of DNA mismatch repair (MMR) p...