Lhx6 deficiency causes human embryonic palatal mesenchymal cell mitophagy dysfunction in cleft palate

• Main Authors: Haotian Luo (Author), Hio Cheng Ieong (Author), Runze Li (Author), Delan Huang (Author), Danying Chen (Author), Xin Chen (Author), Yuqing Guo (Author), Yangqiao Qing (Author), Bingyan Guo (Author), Ruoyu Li (Author), Yungshan Teng (Author), Wenfeng Li (Author), Yang Cao (Author), Chen Zhou (Author), Weicai Wang (Author)
• Format: Book
• Published: BMC, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Overconsumption of retinoic acid (RA) or its analogues/derivatives has been linked to severe craniomaxillofacial malformations, such as cleft palate and midface hypoplasia. It has been noted that RA disturbed the proliferation and migration of embryonic palatal mesenchymal (EPM)...