Endothelial METRNL determines circulating METRNL level and maintains endothelial function against atherosclerosis

• Main Authors: Sili Zheng (Author), Zhiyong Li (Author), Jie Song (Author), Pin Wang (Author), Jian Xu (Author), Wenjun Hu (Author), Yi Shi (Author), Qi Qi (Author), Zhuwei Miao (Author), Yunfeng Guan (Author), Chaoyu Miao (Author)
• Format: Book
• Published: Elsevier, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

METRNL is a recently identified secreted protein with emerging functions. This study is to find major cellular source of circulating METRNL and to determine METRNL novel function. Here, we show METRNL is abundant in human and mouse vascular endothelium and released by endothelial cells using endopla...