Elaidyl-sulfamide, an oleoylethanolamide-modelled PPARα agonist, reduces body weight gain and plasma cholesterol in rats

• Main Authors: Juan Manuel Decara (Author), Miguel Romero-Cuevas (Author), Patricia Rivera (Author), Manuel Macias-González (Author), Margarita Vida (Author), Francisco J. Pavón (Author), Antonia Serrano (Author), Carolina Cano (Author), Nieves Fresno (Author), Ruth Pérez-Fernández (Author), Fernando Rodríguez de Fonseca (Author), Juan Suárez (Author)
• Format: Book
• Published: The Company of Biologists, 2012-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY We have modelled elaidyl-sulfamide (ES), a sulfamoyl analogue of oleoylethanolamide (OEA). ES is a lipid mediator of satiety that works through the peroxisome proliferator-activated receptor alpha (PPARα). We have characterised the pharmacological profile of ES (0.3-3 mg/kg body weight) by m...