A Novel Strategy for the Design of Aurein 1.2 Analogs with Enhanced Bioactivities by Conjunction of Cell-Penetrating Regions

• Main Authors: Fengting Liao (Author), Yuping Chen (Author), Anmei Shu (Author), Xiaoling Chen (Author), Tao Wang (Author), Yangyang Jiang (Author), Chengbang Ma (Author), Mei Zhou (Author), Tianbao Chen (Author), Chris Shaw (Author), Lei Wang (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The rational design modification of membrane-active peptide structures by introducing additional membrane-penetrating regions has become a good strategy for the improvement of action and potency. Aurein 1.2 (GLFDIIKKIAESF-NH₂) is a multifunctional antimicrobial peptide isolate...