Inhibition of Untransformed Prostaglandin H2 Production and Stretch-Induced Contraction of Rabbit Pulmonary Arteries by Indoxam, a Selective Secretory Phospholipase A2 Inhibitor

• Egile Nagusiak: Yoshiyuki Tanabe (Egilea), Maki Saito (Egilea), Yuki Morikawa (Egilea), Akihisa Kamataki (Egilea), Takashi Sawai (Egilea), Masamichi Hirose (Egilea), Koichi Nakayama (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2011-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Involvement of secretory phospholipase A2 (sPLA2) in the stretch-induced production of untransformed prostaglandin H2 (PGH2) in the endothelium of rabbit pulmonary arteries was investigated. The stretch-induced contraction was significantly inhibited by indoxam, a selective inhibitor for sPLA2, and...