A joint transcriptional regulatory network and protein activity inference analysis identifies clinically associated master regulators for biliary atresia

• Main Authors: Panpan Sun (Author), Manhuan Xiao (Author), Huadong Chen (Author), Zhihai Zhong (Author), Hong Jiang (Author), Xuyang Feng (Author), Zhenhua Luo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Biliary atresia (BA) is a devastating cholangiopathy in neonate. Transcription factors (TFs), a type of master regulators in biological processes and diseases, have been implicated in pathogenesis of BA. However, a global view of TFs and how they link to clinical presentations remain explored. Here,...