Novel insights into the synergistic effects of selenium nanoparticles and metformin treatment of letrozole - induced polycystic ovarian syndrome: targeting PI3K/Akt signalling pathway, redox status and mitochondrial dysfunction in ovarian tissue

• Main Authors: Hanem M. Rabah (Author), Darin A. Mohamed (Author), Reham A. Mariah (Author), Sarah R. Abd El-Khalik (Author), Haidy A. Khattab (Author), Norhan A. AbuoHashish (Author), Amal M. Abdelsattar (Author), Mohamed A. Raslan (Author), Eman E. Farghal (Author), Amira K. Eltokhy (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTPurpose Polycystic ovary syndrome (PCOS) has a series of reproductive and metabolic consequences. Although the link between PCOS, IR, and obesity, their impact on the pathogenesis of PCOS has yet to be determined. Dysfunction of PI3K/AKT pathway has been reported as the main cause of IR in P...