miR-155 Modifies Inflammation, Endothelial Activation and Blood-Brain Barrier Dysfunction in Cerebral Malaria

• Main Authors: Kevin R. Barker (Author), Ziyue Lu (Author), Hani Kim (Author), Ying Zheng (Author), Junmei Chen (Author), Andrea L. Conroy (Author), Michael Hawkes (Author), Henry S. Cheng (Author), Makon-Sébastien Njock (Author), Jason E. Fish (Author), John M. Harlan (Author), Jose A. López (Author), W. Conrad Liles (Author), Kevin C. Kain (Author)
• Format: Book
• Published: BMC, 2017-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract miR-155 has been shown to participate in host response to infection and neuroinflammation via negative regulation of blood-brain barrier (BBB) integrity and T cell function. We hypothesized that miR-155 may contribute to the pathogenesis of cerebral malaria (CM). To test this hypothesis, we...