Pentadecapeptide BPC 157, in Clinical Trials as a Therapy for Inflammatory Bowel Disease (PL14736), Is Effective in the Healing of Colocutaneous Fistulas in Rats: Role of the Nitric Oxide-System

• Main Authors: Robert Klicek (Author), Marko Sever (Author), Bozo Radic (Author), Domagoj Drmic (Author), Ivan Kocman (Author), Ivan Zoricic (Author), Tihomir Vuksic (Author), Mihovil Ivica (Author), Ivan Barisic (Author), Spomenko Ilic (Author), Lidija Berkopic (Author), Hrvoje Vrcic (Author), Luka Brcic (Author), Alenka Boban Blagaic (Author), Marijana Coric (Author), Iva Brcic (Author), Dinko Stancic Rokotov (Author), Tomislav Anic (Author), Sven Seiwerth (Author), Predrag Sikiric (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We focused on the therapeutic effect of the stable gastric pentadecapeptide BPC 157 and how its action is related to nitric oxide (NO) in persistent colocutaneous fistula in rats (at 5 cm from anus, colon defect of 5 mm, skin defect of 5 mm); this peptide has been shown to be safe in clinical trials...