Investigation of Drug-Polymer Compatibility Using Chemometric-Assisted UV-Spectrophotometry

• Main Authors: Amir Ibrahim Mohamed (Author), Amr Mohamed Elsayed Abd-Motagaly (Author), Osama A. A. Ahmed (Author), Suzan Amin (Author), Alaa Ibrahim Mohamed Ali (Author)
• Format: Book
• Published: MDPI AG, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A simple chemometric-assisted UV-spectrophotometric method was used to study the compatibility of clindamycin hydrochloride (HC1) with two commonly used natural controlled-release polymers, alginate (Ag) and chitosan (Ch). Standard mixtures containing 1:1, 1:2, and 1:0.5 w/w drug-polymer ratios were...