Stimulation of Neural Stem Cell Proliferation by Inhibition of Phosphodiesterase 5

• Main Authors: Ana I. Santos (Author), Bruno P. Carreira (Author), Rui J. Nobre (Author), Caetana M. Carvalho (Author), Inês M. Araújo (Author)
• Format: Book
• Published: Hindawi Limited, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The involvement of nitric oxide (NO) and cyclic GMP (cGMP) in neurogenesis has been progressively unmasked over the last decade. Phosphodiesterase 5 (PDE5) specifically degrades cGMP and is highly abundant in the mammalian brain. Inhibition of cGMP hydrolysis by blocking PDE5 is a possible strategy...