Chronic aryl hydrocarbon receptor activity phenocopies smoking‐induced skeletal muscle impairment

• Main Authors: Trace Thome (Author), Kayla Miguez (Author), Alexander J. Willms (Author), Sarah K. Burke (Author), Vijayendran Chandran (Author), Angela R. deSouza (Author), Liam F. Fitzgerald (Author), Carolyn Baglole (Author), Maria‐Eleni Anagnostou (Author), Jean Bourbeau (Author), R. Thomas Jagoe (Author), Jose A. Morais (Author), Yana Goddard (Author), Tanja Taivassalo (Author), Terence E. Ryan (Author), Russell T. Hepple (Author)
• Format: Book
• Published: Wiley, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Chronic obstructive pulmonary disease (COPD) patients exhibit skeletal muscle atrophy, denervation, and reduced mitochondrial oxidative capacity. Whilst chronic tobacco smoke exposure is implicated in COPD muscle impairment, the mechanisms involved are ambiguous. The aryl hydroca...