Design, synthesis, and biological evaluation of novel derivatives of dithiodiglycolic acid prepared via oxidative coupling of thiols

• 主要な著者: Olga Bakulina (著者), Anton Bannykh (著者), Mirna Jovanović (著者), Ilona Domračeva (著者), Ana Podolski-Renić (著者), Raivis Žalubovskis (著者), Milica Pešić (著者), Dmitry Dar'in (著者), Mikhail Krasavin (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Human thioredoxin reductase 1 (TrxR1) is a selenocysteine-containing enzyme which plays a crucial role in regulating numerous redox signalling pathways within the cell. While its functioning is important in all cells, levels of TrxR1 expression are higher in cancer cells, possibly as an adaptation t...