Design, synthesis, and biological evaluation of novel derivatives of dithiodiglycolic acid prepared via oxidative coupling of thiols

• Main Authors: Olga Bakulina (Author), Anton Bannykh (Author), Mirna Jovanović (Author), Ilona Domračeva (Author), Ana Podolski-Renić (Author), Raivis Žalubovskis (Author), Milica Pešić (Author), Dmitry Dar'in (Author), Mikhail Krasavin (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human thioredoxin reductase 1 (TrxR1) is a selenocysteine-containing enzyme which plays a crucial role in regulating numerous redox signalling pathways within the cell. While its functioning is important in all cells, levels of TrxR1 expression are higher in cancer cells, possibly as an adaptation t...