Annexin A5 Increases Survival in Murine Sepsis Model by Inhibiting HMGB1-Mediated Proinflammation and Coagulation

• Päätekijät: Jung Hwa Park (Tekijä), Jong-Hwa Jang (Tekijä), Eun Jung Choi (Tekijä), Young Seob Kim (Tekijä), Eun Ji Lee (Tekijä), In Duk Jung (Tekijä), Hee Dong Han (Tekijä), T-C Wu (Tekijä), Chien-Fu Hung (Tekijä), Tae Heung Kang (Tekijä), Yeong-Min Park (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: BMC, 2016-07-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Abstract The identification of HMGB1 as a late mediator in sepsis has highlighted HMGB1 as a promising therapeutic target for sepsis treatment. Recent studies have revealed that annexin A5, a 35 kDa Ca2+-dependent phospholipid binding protein, exerts antiinflammatory effect by inhibiting LPS binding...