Annexin A5 Increases Survival in Murine Sepsis Model by Inhibiting HMGB1-Mediated Proinflammation and Coagulation

• Main Authors: Jung Hwa Park (Author), Jong-Hwa Jang (Author), Eun Jung Choi (Author), Young Seob Kim (Author), Eun Ji Lee (Author), In Duk Jung (Author), Hee Dong Han (Author), T-C Wu (Author), Chien-Fu Hung (Author), Tae Heung Kang (Author), Yeong-Min Park (Author)
• Format: Book
• Published: BMC, 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The identification of HMGB1 as a late mediator in sepsis has highlighted HMGB1 as a promising therapeutic target for sepsis treatment. Recent studies have revealed that annexin A5, a 35 kDa Ca2+-dependent phospholipid binding protein, exerts antiinflammatory effect by inhibiting LPS binding...