Structure-Activity Relationships of Pentacyclic Triterpenoids as Potent and Selective Inhibitors against Human Carboxylesterase 1

• Main Authors: Li-Wei Zou (Author), Tong-Yi Dou (Author), Ping Wang (Author), Wei Lei (Author), Zi-Miao Weng (Author), Jie Hou (Author), Dan-Dan Wang (Author), Yi-Ming Fan (Author), Wei-Dong Zhang (Author), Guang-Bo Ge (Author), Ling Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human carboxylesterase 1 (hCE1), one of the most important serine hydrolases distributed in liver and adipocytes, plays key roles in endobiotic homeostasis and xenobiotic metabolism. This study aimed to find potent and selective inhibitors against hCE1 from phytochemicals and their derivatives. To t...