Radotinib attenuates TGFβ -mediated pulmonary fibrosis in vitro and in vivo: exploring the potential of drug repurposing

• मुख्य लेखकों: Suji Baek (लेखक), Seung Hae Kwon (लेखक), Joo Yeong Jeon (लेखक), Gong Yeal Lee (लेखक), Hyun Soo Ju (लेखक), Hyo Jung Yun (लेखक), Dae Jin Cho (लेखक), Kang Pa Lee (लेखक), Myung Hee Nam (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: BMC, 2022-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Background Tyrosine kinase (TK) plays a crucial role in the pathogenesis of idiopathic pulmonary fibrosis. Here, we aimed to investigate whether radotinib (Rb) could inhibit pulmonary fibrosis by inhibiting TK in vitro and in vivo. Methods The antifibrotic effects of Rb in transforming grow...