Radotinib attenuates TGFβ -mediated pulmonary fibrosis in vitro and in vivo: exploring the potential of drug repurposing

• Main Authors: Suji Baek (Author), Seung Hae Kwon (Author), Joo Yeong Jeon (Author), Gong Yeal Lee (Author), Hyun Soo Ju (Author), Hyo Jung Yun (Author), Dae Jin Cho (Author), Kang Pa Lee (Author), Myung Hee Nam (Author)
• Format: Book
• Published: BMC, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Tyrosine kinase (TK) plays a crucial role in the pathogenesis of idiopathic pulmonary fibrosis. Here, we aimed to investigate whether radotinib (Rb) could inhibit pulmonary fibrosis by inhibiting TK in vitro and in vivo. Methods The antifibrotic effects of Rb in transforming grow...