Imetelstat, a novel, first‐in‐class telomerase inhibitor: Mechanism of action, clinical, and translational science

• Main Authors: Ashley L. Lennox (Author), Fei Huang (Author), Melissa Kelly Behrs (Author), Mario González‐Sales (Author), Neha Bhise (Author), Ying Wan (Author), Libo Sun (Author), Tymara Berry (Author), Faye Feller (Author), Peter N. Morcos (Author)
• Format: Book
• Published: Wiley, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Most cancers and neoplastic progenitor cells have elevated telomerase activity and preservation of telomeres that promote cellular immortality, making telomerase a rational target for the treatment of cancer. Imetelstat is a first‐in‐class, 13‐mer oligonucleotide that binds with high affini...